When it comes to discussing opiates and their effects on the human brain and our abilities to self-control, we must pay special attention to the prefrontal cortex. The prefrontal cortex is located in the most anterior portion of the frontal lobe in the brain. The dendrites (neurological cells) in this part of the brain contain up to 16x as many dendritic spines as neurons in other cortical areas, due to this, the prefrontal cortex integrates a huge amount of information.
The thalamus is a symmetrical structure of two halves, within the vertebrate brain, situated between the cerebral cortex and the midbrain. Some of its functions are the relaying of sensory and motor signals to the cerebral cortex, and the regulation of consciousness, sleep, and alertness. The two parts of the thalamus surround the third ventricle, which contains cerebrospinal fluid, neurons, and fibers that connect the two thalami.
The orbitofrontal cortex is a prefrontal cortex region in the frontal lobes in the brain which is involved in the cognitive processing of decision-making. It is defined as part of the prefrontal cortex that receives projections from the magnocellular medial nucleus of the mediodorsal thalamus, and is thought to represent emotion and reward in decision-making.
Each of the areas of the brain I have just listed are those in the brain most heavily affected by opiates. The opiate receptors are located within the dendrites (neurological cells), which are far more numerous throughout the frontal lobe/prefrontal cortex. As we continue to indulge and abuse powerful opiates like heroin, we are directly deteriorating our ability to self-control. When we inhibit our brain’s ability to function properly, we inhibit our ability to live properly. Sure, it’s up to each individual to define what is proper for them, but we are not talking about ideologies or philosophies, we are talking about physical affects in the brain. If we have a corroded thalamus, we will have a warped perception of sensory and motor stimuli. If we damage our orbitofrontal cortex, we cannot properly make decisions or process cognitive information. When all of these crucial areas are each being harmed and suppressed from developing completely, self-control becomes something that is literally unachievable.
Another important feature of the brain regarding the detrimental effects of substance abuse is glucose. Glucose is the fuel that powers the brain’s many complex functions. Glucose is sugar, also known as blood sugar.
Every day people resist the impulse to go back to sleep, eat unhealthy foods, skip their daily exercise, and take illicit substances. The way by which we avoid such behaviors that feel good in the moment but bear long-term costs is self-control.
If an individual has a choice between an immediate reward or a more valuable reward which they can receive later, the individual will most likely try to control the impulse to take that immediate reward. If an individual has a damaged orbitofrontal cortex, this impulse control will most likely not be as strong, and they may be more likely to take the immediate reinforcement. Additionally, research and experimentation shows a lack of impulse control in children, because the prefrontal cortex develops slowly.
- Beginning addiction before the maturity of this part of the brain can occur, the opportunity for it to develop healthily and completely is endangered, if not completely lost altogether; if not until the substance abuse ceases
- Though many things affect one’s ability to exert self-control, exerting self-control requires sufficient glucose levels in the brain. Reduced glucose and reduced ability to transport it to the brain (known as poor glucose tolerance) are correlated with lower performance in tests of self-control, particularly in difficult new situations (which the life of an addict is plentiful in having)
- Self-control demands that an individual work to overcome thoughts, emotions, and automatic responses/impulses. These strong efforts require higher blood glucose levels, as lower BGL can lead to unsuccessful self-control abilities. (Ex. Alcohol causes a decrease of glucose levels in both the brain and the body, and it also impairs many forms of self-control.)
An untested theory states an alternative explanation of the limited amounts of glucose that are found is that depends on the allocation of glucose, not on limited supply. According to this theory, the brain has sufficient resources of glucose and possibility of delivering, but the personal priorities and motivations of the individual cause the glucose to be allocated to other sites.
What if we succumb to our impulses, not because depletion produces a loss of the ability to exert self-control, but rather it reduces our motivation to do so? Evidence shows that the beliefs, expectations, and motivations one has in regards to particular self-control behaviors can influence performance. Increasing internal or external motivation has been shown to encourage an individual to overcome ego-depletion and ‘tap into’ their remaining resources. Persistence in self-control behaviors also appears linked to an individual’s subjective perception of their resources.
In one particular experiment, participants who believed that self-control can be continually renewed exerted self-control well beyond their counterparts, who believed that their self-control was fixed and limited. Could self-control really be ‘all in your head’? It is plausible that those who believed self-control was limited looked for internal signals to suggest fatigue, and when these signals arouse, their motivation decreased and they prematurely abandoned the task. Alternatively, those with the belief that self-control was more flexible and infinite may have interpreted these signs as cues to work harder to exert self-control, but instead are unwilling or unmotivated, as to do so is unpleasant or requires too much effort or resources. With this evidence in mind, theories have begun to emerge that incorporate the role of motivation in self-control.
How does cognition, affect, and motivation influence self-control depletion? With each act of self-control performed, we become less motivated to engage in further acts of restraint. Simultaneously, we feel more motivated to engage in behaviors that we find rewarding, interesting, and enjoyable. Alternatively, our previous efforts may allow us to feel justified in ‘slacking off’. As one becomes more motivated to gratify impulses, their attention also shifts towards cues signaling gratification and reward. Although preliminary, these impressive findings suggest that repeated self-control exertion weaken the one’s monitoring system, reducing goal-orientated attention. Thus, unintentionally neglect the goal at hand.
True cognition is experienced when we feel our behavior is purely self-regulated and endorsed, and promotes our values and interests. Contexts that support autonomy tend to produce greater self-control outcomes than those that force individuals to restrain themselves. Such a trend has been replicated in various health-related behaviors, such as smoking cessation and alcohol/drug abstinence. Researchers offered two explanations for this finding. Firstly, feeling as though we are the sole agent of our own self-driven regulation is likely to produce a sense of subjective vitality- a positive feeling of aliveness and energy- which may lead to a more rapid recovery of self-control strength. Secondly, ego-depletion effects may be magnified when self-control is exerted in response to external pressures.
To combat/help against depletion of ability to self-control, as it does require energy and focus, and therefore can lessen over time, relaxation, rest, and changing the way one approaches their desires are helpful. The latter is a means to strengthen self-control through applying it to certain behaviors. To overcome unwanted desires, change the approach to such desires. If you are unsure as to what your passion is, take the time to find out. Work out what really matters to you. Let your passion guide you where you can find true fulfillment.
To aid in discovering your desires;
- take an inward look and become aware of what sort of motivation drives you through life.
- Break your old patterns, try something new, try something different.
- Go skydiving, eat something you’ve never eaten before, or drive a different way to work.
- Do something for others, spend the time doing things YOU want to do.
- After that day, or that week, integrate your discovered passions and style of living into your everyday life.
Because we all have responsibilities and priorities, convention obviously needs to be followed to a certain extent, but life is ending one day at a time, and living the way you want is possible.
In the next ‘Here to Help’, I will go into detail about ‘goals and motivation’. Since we now know so much about self-control and emotion-regulation, we have a good foundation for understanding motivation; and motivation is required for not only self-control, but setting and achieving goals, too. So tune in next time and hopefully learn something new. Thanks for reading, and God Bless.





